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PIA Overview:
Reserve, Resilience and Protective Factors

Chair: Yaakov Stern Co-chairs: Gaël Chételat and Michael Ewers

The Reserve, Resilience and Protective Factors PIA will focus on epidemiologic, clinical/neuropsychological and neuroimaging/biomarker approaches to understanding reserve and resilience. A major emphasis will be placed on potential underlying  structural and functional brain mechanisms. The PIA will also explore intervention strategies that target mechanisms underlying reserve or resilience in order to promote individual brain health and prevent or delay the onset of dementia.

Our initial objectives are to:

  1. Establish a collaborative forum and network to foster knowledge and research on the mechanisms that may promote reserve and resilience and help prevent or delay cognitive aging and Alzheimer’s disease.

  2. Develop consensus guidelines on research criteria for studying brain reserve and resilience, and propose strategies to investigate the different underlying brain mechanisms (neuroprotective or compensatory).

  3. Promote collaborative projects on the topic, including joint prospective neuroimaging studies, joint grant applications, and merging data sets collected by PIA members.


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