PIA Overview:
Immunity and Neurodegeneration

Bruce Lamb, Chair
Donna Wilcock, Vice Chair
Dana Zimmer, Communications Chair
Marcia Gordon, Program Chair
Christopher Norris, Steering/Executive Committee Member
Dauphine Boche, Steering/Executive Committee Member
Guillaume Dorothee, Steering/Executive Committee Member

Accumulating genetic, epidemiological, biochemical and histological studies as well as brain imaging and clinical studies suggest that both peripheral and central immune cells likely play a critical role in the development and progression of Alzheimer's disease and related disorders, including many other neurodegenerative diseases. These findings also suggest an opportunity for the development, characterization and testing of novel therapeutic targets focused on immunity in AD. The Immunity and Neurodegeneration PIA seeks to serve as a unique working group of basic, translational and clinical researchers working on all aspects of both adaptive and innate immunity to stimulate interdisciplinary research, develop consensus, identify knowledge gaps on issues critical to the field, and integrate and promote investigators in the field.  Given that many of the key findings linking immunity to Alzheimer's disease and neurodegeneration have occurred within the past few years, development of this PIA provides a unique opportunity that currently does not exist, to integrate, promote and facilitate immunity-focused Alzheimer’s research.

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